Day 1 :
- Cancer Cytopathology | Comparative Pathology | Head & Neck Pathology | Renal Pathology | Hematopathology | Surgical Pathology | Clinical Pathology | Diagnostic Pathology | Oncopathology | Reproductive Pathology | Neuropathology
New York Presbyterian Hospital-Weill Cornell Surgical Pathology, New York, U.S.A.
Rebecca Baergen has expertise in perinatal and placental pathology with a concentration on how placental pathology can explain adverse outcome, mechanisms of injury and diagnose underlying maternal and fetal disease. She has built her practice and consultation service after years of experience in clinical evaluation of placental specimens, research, and teaching of medical students, resident physicians and pathologists. She has also experience in many extramural courses of perinatal pathology hosted by many education organizations throughout the world.
Background: Preeclampsia (PEC), systemic lupus erythematosus (SLE), and antiphospholipid antibody syndrome (aPLA) are associated with adverse maternal and fetal outcomes but the pathogenic mechanisms have not been well studied. Methodology: We investigated the expression of complement activation products and inflammatory biomarkers in these patient groups. We compared each group with control patients who had an unremarkable clinical history and no pathologic placental findings. Immunohistochemistry for C3b, C4d, Annexin A5 (A5), and C5b-9 was performed; staining was graded on intensity (0, 1+, 2+, 3+) and distribution (absent, patchy, diffuse). 70% of PEC patients, 50% of SLE patients and 20% of aPLA patients showed at least weak, focal staining for C4d, while controls were negative. A5 staining showed focal loss in all disease groups, while controls did not. C3b staining showed more frequent strong staining in disease groups than controls. C5b-9 staining was localized to areas of fibrin deposition or infarction in all groups. Conclusion and Significance: Previously, aPLA-associated pregnancy complications have been thought to be a consequence of a unique aPLA pathogenic mechanism. However, the similarity of the IHC findings in aPLA placentas to those from SLE and PE patients - i.e. increased complement deposition and loss of A5 expression - suggests that aPLA-associated pregnancy complications may reflect a more general autoimmune mechanism, such as localized deposition of immune complexes and that this mechanism may be operating in other disease conditions associated with poor maternal and fetal outcome.
Dr. Mitrasadat Rezaei worked as Assistant professor of pathology at Flowcytometry department, High Institute for research and education in blood transfusion medicine, Tehran, Islamic Republic of Iran from 2011-2014. Currently she is working as Assistant professor of pathology at pathology department, National Research Institute of Tuberculosis and lung disease, Shahid Beheshti University of Medical Science,Tehran,Iran, from 2014 and she is the Director of Molecular pathology Laboratory , Masih Daneshvari Hospital from 2014 and she is the Head of cental lab in school of medicine, Shahid beheshti University of Medical Science, Tehran, Iran from 2016.
Necrotizing SarcoidGranulomatosis(NSG) is a rare granulomatous pneumonitis which is composed of background of sarcoidosis-like granulomas with granulomatous vasculitis and variable amount of necrosis .We reported a case of 38-year-old non-smoking woman presented by left-sided chest pain and dyspnea for three days.Chest CT scan exhibitedcollapse consolidation of left lower lobe with presence of two septated small sized cystic lesions within collapsed segment.Video-Assisted Thoracic surgery (VATS) was performed and histologicalexamination confirmed the diagnosis by excluding other causes of granulomatousdisease.The prognosis of NSG is favorable and medical treatment is usually not necessary,as well as our case.
NSG is a rare disease with nonspecific symptoms and good prognosis which frequently confused with Wegener’s granulomatosis,sarcoidosis and churgstrauss.this entity should also be considered as differential diagnosis of necrotizing granulomatous diseases.
Services institute of medical sciences, Lahore, Pakistan
DR Hira Kareem has completed her post graduation from University of Health Sciences Lahore at the age of 28 years.currently serving as a demonstrator in Services Institute of Medical Sciences Lahore.She has published two medical papers on reputed journels.
To evaluate the effects of copper preparations of Kushta on renal parameters. This study was conducted from 14th of may 2013 to 30th of November 2013 in Pathology Department of University of Health Sciences Lahore and it was an experimental study.Method:Thirty albino rats were selected and divided into three groups. The control group A was fed on standard pellet rodent diet and tap water. The experimental group B was fed single dose of copper preparation of Kushta(0.15mg/kg of body weight) for 18 weeks while experimental group C was fed double dose of copper preparation of Kushta(0.30mg/kg of body weight) for 18 weeks.Renal parameters were calculated once at the start of experiment and then after every 6 weeks upto 18 weeks. Results: Results showed that renal parameters in terms of serum creatinine level and proteinuria were deranged evident on biochemical analysis. When the control group A on normal diet was compared with the experimental group B and Statistically significant difference (p<0.05) was noticed in terms of renal parameters.
Conclusion: It is therefore concluded that copper preparations of Kushta deranged renal parameters in terms of serum creatinine levels and proteinuria