13^th European Pathology Congress August 02-03, 2017 Milan, Italy

2003 -Degree in Medicine and Surgery, University of Milan, Milan, IT\r\n2007\r\nSpecialization in Radiodiagnostics, University of Milan, Milan, IT\r\n\r\nPROFESSIONAL EXPERIENCES\r\nFrom 2008 reader for the mammographic screening service organized by the ASL Milano2 (Certified Diploma in senology issued by ISPO, Florence, 2006\r\n\r\nPUBLICATION Collaboration on the research activities of the Radiology Unit of the IRCCS Policlinic San Donato , with 8 articles published in PubMed indexed journals with impact factor.\r\n

INTRODUCTION AND OBJECTIVES : The aim of this study is to check the possibility to use the test with micronuclei in saliva, for cases doubts, detected in screening for breast cancer\r\nMATERIAL AND METHODS It is been executed a bibliographic search on Pub Med (MEDLINE) ,Home Genetic Reference, for articles published from Jan 1, 2000 to Dec 31, 2016,for the keywords : \"micronuclei in exfoliated buccal cells in breast cancer “ The key words are used in the research in free text, and with cross –referencing method application. Another search it is been made for “MN in breast cancer “,from Jan1 2014 to today.\r\n RESULTS Five studies show that in buccal cells, in breast cancer , the amount of MN are significantly higher than compared to benign cases as in six studies for the detection of micronuclei in needle aspirates ductal,. Contrasting results are for MN in peripheral blood lymphocytes\r\nDISCUSSION . The micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast cancer, while the tests in peripheral blood lymphocytes , have known reproducibility problems .The references show also,that is an increase of MN in exfoliated buccal mucosa cells test, May be interesting to apply the MN scoring in cases of doubt, according to functional BI-RADS category 3 (probably benign), and which are sent to a successive control\r\nCONCLUSIONS: it has verified that in buccal cells, in cases of breast cancer is significantly higher than the number of MN compared to benign cases, indicates the possibility of applying this technique in cases of doubt, in oral saliva

Dr. Salma AlDalla has completed her PhD at the age of 32 from The University of Manchester, UK. She has published 14 articles in reputed journals and has a work experience in Haematology & Blood Bank Laboratory. She has also published several papers in national and multinational journals. She is the senior of training courses of Haematology technicians in General Hospital Laboratory in Kuwait.

Hereditary spherocytosis (HS) is a heterogeneous group of hemolytic anemia caused by deficiency or dysfunction of red blood cell (RBC) cytoskeletal proteins. It is a common disorder located mostly in Caucasian population; most affected individuals have mild or only moderate hemolysis. In a few rare cases, the measurement of RBC membrane proteins is required to clarify the nature of the membrane disorder in absence of the family history. Patients with HS are at more risk of developing gallstones, whose prevention represents a major impetus for splenectomy in such patients. The main purpose of the study is to perform a mini review on the formation of gallstones in patients with hereditary spherocytosis. Hence, regular ultrasound and other diagnostic examinations are recommended for timely detection of any presence of gallstones in patients with HS.

Abeer Refaiy is an assistant professor at Assiut University since 2007. She has completed her MD at the age of 34 years from Assiut University. Her research interest includes pathology and tumor markers. She has published more than 12 papers in reputed journals. She is currently working on a bladder cancer project.

Tumor microenvironment is an emerging player in many solid tumors. Hodgkin lymphoma (HL) characterized by paucity of tumor cells and extensive collection of non malignant cells which contribute to tumor micoenvironment together with other interacting molecules and blood vessels. CD163 has been recognized as a valuable specific macrophage marker. Cyclo-oxygenase 2 (Cox2) plays a role in tumor progression and carcinogenesis and expressed in many malignant and non malignant cells. The aim of this study is to examine the expression of CD163, CD31 and Cox2 in classic Hodgkin lymphoma. Expression of CD163, CD31 and Cox2 were examined in patients with HL by immunohistochemistry. Eighty three patients were included in this study, 40 patients were males (48.19%) and 43 (51.81%) females. High CD163 was found in 59 patients (71.08 %) and low expression in 24 (28.91%). Cox2 was positive in 52 patients (62.65%) and negative in 31 of cases (37.34%).\r\nThere were significant correlations between expression of CD163 and Cox2 (p=0.01), Cox2 and CD31 (p=0.017) and between CD31 and CD163 (p=0.042). Significant correlations were detected between CD163, Cox2, and tumor stage (p=0.001, and 0.01) respectively, but not with CD31 (p=0.5). CD31 showed significant correlation with histological subtype (p=0.04). Regarding survival analysis, a significant relationship was found between Cox-2 expression with relapse rate and disease free survival (DFS) (p= 0.027, 0.0379) respectively. Higher CD163 expression was found in relapsed cases (p=0.08). In conclusion, expression of CD163 and Cox-2 might be helpeful to predict relapse in patients with Hodgkin lymphoma. \r\n

Azadeh Memarian has completed her Forensic medicine speciality at the age of 34 years from Iran University of medical sciences, Tehran,Iran.

Respiratory, central nervous system, and skin complications of mustard gas toxicity have previously been studied; however, the liver and kidney side effects due to this intoxication have not been fully noted. We aimed to evaluate the frequency of liver, kidney and lung lesions in mustard gas-exposed Iranian veterans who had been exposed to the toxin almost 2 decades before. A total of 100 veteran bodies underwent autopsy by at least two forensic medicine specialists. The liver, kidney and lung specimens were sent for pathological examination and their lesions, severity of the lesions, and the relation between the type/severity of the lesions and the time elapsed since their appearance were studied.A total of 83%, 63%, and 62% of the veterans had lung, liver, and kidney pathologies.The most common pathologies included liver steatosis, interstitial fibrosis of the kidney, and lung atelectasis. Liver and kidney pathologies are far more common than what is considered in the mustard gas-exposed veterans. These pathologies are often accompanied by very severe lung complications. Many studies have evaluated the pathologies developing after exposure to chemical gases.However, few studies have concentrated on the complications and pathologies of the liver and kidney in these patients. Our results show that despite what is generally assumed, severe and fatal pathologies of the liver and kidney are common in these patients.