Tomasz S. Tkaczyk
Rice University, USA
Title: Multimodal in-vivo imaging strategies for early cancer diagnostics
Biography
Biography: Tomasz S. Tkaczyk
Abstract
Monitoring and diagnostics of many cancers like oral, cervical or esophageal adenocarcinoma often require multimodal approach to perform successful diagnostics. Both morphological imaging and spectral assessment are important tools used in these applications. When, used separately, either method cannot easily achieve both high sensitivity and specificity in vivo. On the other hand if combined and working in tandem they can significantly improve the diagnostic performance. Therefore this presentation focuses on analysis of multimodal approaches/instrumentation for early in vivo cancer detection. Two groups of devices will be discussed: (1) miniature-integrated imaging microscopes (endomicroscopes) to provide morphological content and (2) multi and hyperspectral high speed systems to obtain bio-chemical signatures of the tissue. Practical aspects of multi-modal system integration, performance and parameters (field of view and resolution of individual sub-systems) will be discussed together with the design considerations to optimize its effectiveness. Number of imaging methods will be presented including (for morphological assessment): contact imaging, confocal, structure illumination, and multi-photon imaging and (in area of spectral detection) narrow band imaging (NBI), image mapping spectrometry IMS, array snapshot systems in number of cancer applications (including for example oral, cervical, and esophageal adenocarcinoma).