Qing Kay Li
The Johns Hopkins Medical Institutions
Title: Accurate sub-classification of lung cancer using small biopsy samples based on updated WHO and IASLC criteria.
Biography
Biography: Qing Kay Li
Abstract
The new 2015 edition of the WHO classification and recommendations of IASLC (International Association of Study of Lung Cancer) emphasize the importance of accurate subclassification of lung cancers for targeted therapy. Lung cancer is a heterogeneous group of neoplasms and accurate diagnosis and sub-classification on small biopsies can be challenging. Recent systematic reviews and meta-analyses have shown that interobserver disagreement rates on the subclassification of non–small cell lung cancer (NSCLC) are approximately 10-20% in resected specimens and 20-30% in small biopsy specimen without immunohistochemical (IHC) stains. The morphological heterogeneity of the lung cancer is also correlated with certain molecular alterations. Therefore, it is necessary to introduce newly updated guidelines of WHO and IASLC into our daily practice to improve the accuracy of subclassification of lung cancer for targeted therapy, particularly in small biopsy specimens.